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Smarter Analytics Clan Radio

Satnam Alag, VP of Engineering, NextBio

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Thank you everybody!

Hope to meet you all next time!

Rank: Cave Painter

Thanks everyone for joining us.  More radio fun next week!

Thinkernetter

Satnam. thank you for taking the time to talk with us.  I've been looking forward to your talk for several weeks.  

IQ Crew

Thank you.  If you are in Atlanta I will set up some meetings at Georgia Tech.

 

Thanks,

Will

Thinkernetter

Satnam, thanks for generously sharing your time.

Thinkernetter

Very user friendly, and nice elephant cartoons:  http://hadoop.apache.org/

Thinkernetter

Thank you all for participating. satnam

Rank: Cave Painter

wfoster8560 -- there are a number of white papers on hadoop, the apache hadoop site is a good reference, the original Google papers (2003 on Google file system, 2004 on MapReduce), along with the Oreilly and manning books on Hadoop are all good sources. satnam

Rank: Cave Painter

Georgia Tech library doesn't own your book.  I will rectify this.

 

Will

Thinkernetter

What is the best way to understand the possibilities of Hadoop and how to use it?

 

Will

Thinkernetter

wfoster -- I dont think we are collaborating with Georgia Tech, but would love to if there is similar interest. satnam

Rank: Cave Painter

Lin -- yes, 2008 CI book had Java-based examples. Java continues to be the programming language i use, so most probably the next book will also be Java based. satnam

Rank: Cave Painter

wfoster8560 -- since 2008, I have been surprised at how rapidly new user-generated content is being generated. The whole emergence of Big Data and use of Hadoop to mine information has been a positive surprise. satnam

Rank: Cave Painter

Kim -- Google, Yahoo, Facebook all have shown how one can scale to hundreds of petabytes of data. We are very confident that we will similarly scale to large volumes. satnam

Rank: Cave Painter

Satnam, I understand that your original book had Java-based techniques.  If you wrote another book, would it also be Java-based?

IQ Crew

Your book was published in 2008.   What have been the big breakthroughs that you did not anticiapte?

Will

Thinkernetter

wfoster8560 -- I have not heard about the project of China sequencing every chinese. But if it is true it will be great to have that data publicly available for researchers to get new insights. satnam

Rank: Cave Painter

Satnam, there doesn't seem to be a realistic alternative to the cloud for the kind of scaleable data storage you need.  Are you at all concerned about outages, data loss, security breaches and the other (supposed) downsides of the cloud?

Thinkernetter

Mary -- intelligent search, mining of large amounts of data using Hadoop is fairly general. The techniques are applicable to most verticals that deal with large amounts of data. satnam

Rank: Cave Painter

lin -- there are a number of examples of how molecular medicine is being used -- breast cancer being another example. I would say we are in the area of Translational Research/Medicine. By our partnership with CCI and other to follow, we hope to move the field forward towards the clinic. satnam

Rank: Cave Painter

@Satnam: In addition to healthcare, is there any other field where you envision your techniques could be applied?

Thinkernetter

Kim -- self learning algorithms. yes, NextBio is a data-driven engine and answers may change as new data comes along. we still have a lot more room on how further to mine the large amounts of data using additional machine learning algorithms. satnam

Rank: Cave Painter

Satnam, is molecular medicine a real possibility at this time?  The only one I know well, Dendreon, has a patient-specific DNA treatment for prostate cancer -- the only things I hear about them is their financial and regulatory troubles.  Is molecular medicine commercially viable or is it just research?

IQ Crew

Is there any truth to the rumor that the Chinese government is going to sequence

the genome of every Chinese and combine it with hereditary records?   What will be the impact on genomic medicine?

 

Will

 

Thinkernetter

Question I ran out of time for: are there AI capabilities in the NextBio platform - in other words, does machine learning enable it to improve its own research strategies?

Thinkernetter

Satnam:

Are you doing any work with Georgia Tech in Atlanta (my university)

Will

Thinkernetter

That's going to be part of the Cancer Care Institute collaboration, right?

Thinkernetter

wfoster8560 - no we are do not have a specific project with China. satnam

Rank: Cave Painter

Kim -- there is a lot of work going on in the area of wellness and preventive treatment. There are a few examples -- dosage of drugs and biomarkers for diseases based on molecular data. Oncology is one of the top areas where molecular medicine is being used. satnam

Rank: Cave Painter

Thank you, Satnam.

Thinkernetter

Do you work with China on genome projects and sharing of data between US and China?

 

Thinkernetter

Mary -- yes, we build multiple tenancy into our architecture. All data is tagged with a userid or a domain id that allows us to segregate data logically. satnam

Rank: Cave Painter

Satnam, are we still a long way away from the day when preventive treatment (or therapy) will be prescribed based on an individual's DNA?

Thinkernetter

BTW, many thanks for a great interview, Satnam!

Thinkernetter

Satnam: Are you running across the public Internet or pathways like Internet2?

Rank: Cave Painter

@Satnam: Is the single instance multiple tenant architecture supported in your open source technology?

Thinkernetter

wfoster8560 -- that sounds like a fascinating problem. I havent worked on this problem. satnam

Rank: Cave Painter

Mitch -- Singel instance multiple tenant architecuter -- same set of hardware serving multiple tenants. Logical partitioning of data. satnam

 

Rank: Cave Painter

Satnam:

   Do you have any experience using social media fed multi-agent models to find tipping points in society?

 

Thinkernetter

@Mitch. Indeed. 

Rank: Cave Painter

@Mitch: What do you mean by shared hosting? Multisite sharing?

Thinkernetter

Marden - Automation is key. Manual processes can't work fast enough or in great enough volume. 

Thinkernetter

Mary, open source platforms generally excel on open source and security. It's more an issue of shared hosting. 

Thinkernetter

There seem to be some trends appearing in dealing with large data sets:

- Let algorithms discover trends;

- Collect data from multiple sources;

- Associate data with related data immediately (real time)

- Utilise autonomic sensors to capture data.

Rank: Cave Painter

@Satnam: Is HPC (high performance computing) a platform you see as suitable for the kind of data you're describing?

Thinkernetter

Great point, Mitch. I'm not sure how the open source technologies Satnam is referring to treat those issues of performance and security.

Thinkernetter

Does that raise issues of performance -- if one client is using a lot of resources does it bog down the others? Security? What if one client comes under DoS attack; how are other clients protected?

Thinkernetter

wfoster8560 - Yup, right here at this URL. 

Thinkernetter

Will this interview be archived for access by others in the future?

 

Thinkernetter

not clear !

Rank: Cave Painter

@Mitch: Yes, thinking of that Human Genome Data; seems curious.

Thinkernetter

I'm waiting for this topic!

Hopefully I will learn good things today!

Rank: Cave Painter

Re: data cleansing. Maybe with huge data sets, the anomolies are statistically washed out. Oh, he just suggested the same.

Rank: Cave Painter

Hello, certain771! Welcome to the Internet Evolution Smarter Analytics Clan Radio!

Thinkernetter

120 gigs of data doesn't actually sound like a lot for an entire genome. Even a half-terabyte -- that's less than the hard disk on a Mac. But when you're dealing with millions of sets of that type - that's a lot of data. 

Thinkernetter

Hello everybody!

(a litte bit late!!!)

Rank: Cave Painter

Awareness yes. Always worried when it's in the early hype phase. Want to get more of us to the useful phase.

Rank: Cave Painter

We have seen awareness of big data really take off, no?

Thinkernetter

Alternately, you can shut down the browser and restart it, or try a different browser. Chrome seems to work pretty well. 

Thinkernetter

@MField: Hm. I'd suggest shutting the tab and refreshing with a new one

Thinkernetter

I am havingv audio problems with the intro repeating every 2 seconds and drowning out the speakeer

Rank: Cave Painter

Refresh your browsers if you're having trouble w/ the audio.

Thinkernetter

Hello Everyone!

Rank: Cave Painter

Thx, Mitch, audio now.

 

Rank: Cave Painter

Welcome to Mitch on his first IE Radio sojourn!

Thinkernetter

wfoster850, it should start plaing automatically.... now. You should be hearing music. 

Thinkernetter

Mitch, that is normally me too.  But I am so excited to hear this talk that I am early today.

IQ Crew

How do I get the Radio Feed?

 

Thinkernetter

Am I on the right link for the 2 pm broadcast - I dont hear anything?

 

Rank: Cave Painter

*fastening protective harness* 

Ready!

Thinkernetter

This is my first IERadio event but my experience with other events of this type is that everybody arrives in the first three minutes. 

Thinkernetter

Everbody ready?

Thinkernetter

No, I see a few more names in the scroll. Stantracy, Kim, and Satnam. 

Thinkernetter

Hey back, Mitch.  Are we the only two here now?

IQ Crew

when will we receive our starbucks cards

Rank: Cave Painter

Good to see you here already Satnam.  We'll be speaking very shortly.  @Dkap: starting at 2pm ET.

Thinkernetter

Honored to be speaking live in an hour. Satnam

Rank: Cave Painter

when does this start

 

 

Rank: Cave Painter
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